https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39540 Wed 27 Jul 2022 14:22:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45189 In situ hybridisation revealed that polyI:C offspring had: (1) SST mRNA reductions in the cingulate cortex and nucleus accumbens shell, regardless of MIA timing; (2) SSTR2 mRNA reductions in the cortex and striatum of GD19, but not GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected reduction of PVALB mRNA in the infralimbic cortex, and; (4) no alterations in inhibitory markers in hippocampus. Maternal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not hippocampus. These results show lasting inhibitory-related deficits in cortex and striatum in adult offspring from MIA. SST downregulation in specific cortical and striatal subregions, with additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the adult behavioural changes resulting from MIA and its timing.]]> Wed 26 Oct 2022 14:26:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16819 Wed 11 Apr 2018 17:19:46 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20577 Wed 11 Apr 2018 12:29:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33905 Tnfa, mitogen-activated protein kinase 8 (Mapk8/Jnk1), and growth differentiation factor 9 (Gdf9) (P < 0.05). Mass spectrometry and cell signaling pathway analysis indicated upregulation of cellular pathways associated with acute phase signaling, and cellular survival and assembly. Apoptosis assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling indicated significantly increased positive staining in the ovaries of LPS-treated neonates. These findings suggest that increased proinflammatory signaling within the neonatal ovary may be responsible for the LPS-induced depletion of the primordial follicle pool. These findings also have implications for female reproductive health, as the ovarian reserve is a major determinate of female reproductive longevity.]]> Wed 09 Feb 2022 15:58:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50563 Tue 01 Aug 2023 10:18:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40979 Thu 21 Jul 2022 09:06:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49926 Thu 15 Jun 2023 11:48:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29247 Sat 24 Mar 2018 07:36:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29233 Sat 24 Mar 2018 07:36:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24453 Sat 24 Mar 2018 07:17:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38431 Mon 29 Jan 2024 18:00:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43587 Mon 26 Sep 2022 13:48:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33142 Mon 03 Sep 2018 12:55:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36750 Fri 03 Jul 2020 09:05:42 AEST ]]>